Peer-reviewed veterinary case report
Effective treatment of an orthologous model of autosomal dominant polycystic kidney disease.
- Journal:
- Nature medicine
- Year:
- 2004
- Authors:
- Torres, Vicente E et al.
- Affiliation:
- Mayo Clinic College of Medicine · United States
Abstract
Autosomal dominant polycystic kidney disease (ADPKD) is a leading cause of end-stage renal disease. The vasopressin V2 receptor (VPV2R) antagonist OPC31260 has been effective in two animal models of PKD with pathologies that are probably related. Here we show, in a mouse model of ADPKD (Pkd2(-/tm1Som)), a similar cellular phenotype and response to OPC31260 treatment, with reduction of renal cyclic AMP (cAMP) levels, prevention of renal enlargement, marked inhibition of cystogenesis and protection of renal function.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14991049/