Peer-reviewed veterinary case report
Effectiveness of a modified administration protocol for the medical treatment of canine pyometra.
- Journal:
- Veterinary research communications
- Year:
- 2015
- Authors:
- Contri, Alberto et al.
- Affiliation:
- Department of Veterinary Clinical Sciences · Italy
- Species:
- dog
Plain-English summary
Pyometra is a serious infection of the uterus that can affect female dogs who have not been spayed. In this study, researchers looked at a new way to give a medication called aglepristone to treat this condition in 73 female dogs aged between 2 and 14 years. The dogs were split into two groups: one received the standard treatment, which worked for about 88.5% of them, while the other group followed the new treatment schedule, which was successful for all of them. The modified treatment not only cleared the infection but also showed no signs of returning over the next two years, and the dogs returned to normal reproductive health. Overall, the new treatment method proved to be very effective.
Abstract
Pyometra is one of the most common diseases in intact bitches. The aim of this study was to evaluate the effectiveness of a modified aglepristone protocol for the medical treatment of pyometra in the bitch. Of these, 73 bitches affected by pyometra of different breeds and age (2-14 years old) were enrolled. They were randomly assigned to a control group (CTG - 26 bitches) treated with classical protocol (aglepristone at 0, 1 and 6 days - day 0 = day of the diagnosis) and a modified treated group (MTG - 47 bitches) treated with a different administration protocol (aglepristone at 0, 2, 5 and 8 days). The classical protocol with the anti-progestagen aglepristone was effective in 88.5 % (23/26) of CTG bitches while the modified protocol was effective in all (47/47) of MTG bitches. One of the 23 CTG bitches received a further administration on day 14, which resolved the pyometra, while in the three cases of CTG bitches, in which the treatment was ineffective, an ovariohysterectomy was carried out. The modified protocol showed a success rate of 100 %, compared with the classical protocol proposed in the literature, and no recurrence of the disease was recorded in the 24 months follow up. After treatment, the oestrus onset was earlier than expected (interoestrus of 128 ± 32 days). In this study, the modified treatment protocol showed high efficacy and lack of recurrence within 24 months, suggesting a complete recovery of reproductive function in the bitch, with a normal fertility.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/25323020/