Peer-reviewed veterinary case report
Maropitant works better than ondansetron to stop vomiting in dogs
By Burke, Jasper E et al.·Published in Journal of the American Veterinary Medical Association·2021·View original on PubMed →
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Original publication title: Effectiveness of orally administered maropitant and ondansetron in preventing preoperative emesis and nausea in healthy dogs premedicated with a combination of hydromorphone, acepromazine, and glycopyrrolate.
- Species:
- dog
Plain-English summary
A group of healthy rescue dogs was given either maropitant or ondansetron two hours before receiving a combination of medications for sedation. The dogs that received maropitant had significantly less vomiting and nausea compared to those that did not receive any anti-nausea medication. While ondansetron also helped reduce nausea, it was not as effective as maropitant in preventing vomiting. Overall, maropitant proved to be the better option for keeping dogs comfortable before surgery.
People also search for: dog vomiting after surgery · anti-nausea medication for dogs · maropitant for dog nausea · ondansetron for dogs · dog preoperative care
Abstract
OBJECTIVE: To compare effectiveness of maropitant and ondansetron in preventing preoperative vomiting and nausea in healthy dogs premedicated with a combination of hydromorphone, acepromazine, and glycopyrrolate. ANIMALS: 88 dogs owned by rescue organizations. PROCEDURES: Dogs received maropitant (n = 29) or ondansetron (28) PO 2 hours prior to premedication or did not receive an antiemetic (31; control). Dogs were evaluated for vomiting, nausea, and severity of nausea (scored for 6 signs) for 15 minutes following premedication with hydromorphone, acepromazine, and glycopyrrolate. RESULTS: A significantly lower percentage of dogs vomited after receiving maropitant (3/29 [10%]), compared with control dogs (19/31 [62%]) and dogs that received ondansetron (15/28 [54%]). A significantly lower percentage of dogs appeared nauseated after receiving maropitant (3/29 [10%]), compared with control dogs (27/31 [87%]) and dogs that received ondansetron (14/28 [50%]), and a significantly lower percentage of dogs appeared nauseated after receiving ondansetron, compared with control dogs. Nausea severity scores for hypersalivation, lip licking, hard swallowing, and hunched posture were significantly lower for dogs that received maropitant than for control dogs, and scores for hypersalivation, lip licking, and hard swallowing were significantly lower for dogs that received ondansetron than for control dogs. CONCLUSIONS AND CLINICAL RELEVANCE: Oral administration of maropitant 2 hours prior to premedication with hydromorphone reduced the incidence of vomiting and the incidence and severity of nausea in healthy dogs. Oral administration of ondansetron reduced the incidence and severity of nausea but not the incidence of vomiting.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/34914630/