Peer-reviewed veterinary case report
Tapentadol for orthopedic pain relief in dogs with leg lameness
By Kieves, Nina R et al.·Published in The Canadian veterinary journal = La revue veterinaire canadienne·2020·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
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Original publication title: Effectiveness of tapentadol hydrochloride for treatment of orthopedic pain in dogs: A pilot study.
- Species:
- dog
Plain-English summary
A group of dogs with limping in their back legs due to a torn knee ligament were given an oral pain medication called tapentadol to see if it would help. After taking the medication, the dogs showed less pain based on owner assessments, but there wasn't a noticeable change in how they walked. The treatment appeared safe, with no major side effects reported. While the dogs felt better after four hours, more research is needed to find the best dosing for long-term pain relief.
People also search for: dog limping treatment · tapentadol for dogs pain · knee ligament injury in dogs
Abstract
This pilot study evaluated the short-term analgesic effect of oral tapentadol hydrochloride (tapentadol) in dogs with unilateral hind limb lameness secondary to naturally occurring cranial cruciate ligament rupture. Baseline data including pharmacodynamic parameters, sedation scores, lameness scores, and objective gait analyses were collected. Tapentadol was administered orally (30 mg/kg body weight). Four hours following administration of tapentadol all data were collected again. Plasma concentrations of tapentadol 4 hours after administration were assessed using high performance liquid chromatography tandem mass spectrometry. No significant side effects were noted. All dogs had measurable plasma concentrations of tapentadol (mean concentration: 18.9 ng/mL). There were no significant differences in pharmacodynamic parameters or sedation over time. Subjective lameness scores were significantly lower than baseline at 4 hours post-drug administration. No significant improvement was seen in objective gait analysis. Further studies are needed to assess dosing regimens which may lead to effective treatment of acute pain and long-term use.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/32165753/