Peer-reviewed veterinary case report
Safety and effects of iopanoic acid in cats on levothyroxine
By Gallagher, Alexander E & Panciera, David L·Published in Journal of feline medicine and surgery·2009·Department of Small Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Effects and safety of iopanoic acid in cats administered levothyroxine.
- Species:
- cat
Plain-English summary
Thirteen cats with hyperthyroidism were treated with levothyroxine for 42 days, and then given either a placebo or iopanoic acid for 14 days to see if it would help lower their thyroid hormone levels. The results showed that both doses of iopanoic acid significantly reduced the levels of T(3), a hormone associated with hyperthyroidism, compared to the placebo group. However, the treatment did not seem to improve the cats' clinical signs of hyperthyroidism. More research is needed to understand the long-term effects of iopanoic acid in cats with this condition.
People also search for: cat hyperthyroidism treatment · iopanoic acid for cats · levothyroxine side effects in cats
Abstract
The purpose of this study was to evaluate the safety and effect of iopanoic acid in 13 cats with hyperthyroidism induced by daily subcutaneous administration of 25microg/kg levothyroxine for a period of 42 days. On day 28 of levothyroxine administration, cats were randomly allocated to receive treatment twice daily with a placebo (control group; n=4), 50mg iopanoic acid (low dose group; n=5), or 100mg iopanoic acid (high dose group; n=4) for 14 days. Compared to the control group, T(3) concentrations were significantly decreased in both the low dose and high dose groups on days 35 and 42. T(3) concentrations in the low dose and high dose groups at days 35 and 42 were not different from day -8. The effect of iopanoic acid on clinical signs of hyperthyroidism was less apparent. Further clinical studies evaluating the long-term effect in cats with spontaneous hyperthyroidism are warranted.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/18786844/