Peer-reviewed veterinary case report
Effect of 0.02% netarsudil eye drops on eye pressure in healthy dogs
By Yang, Vanessa Y et al.·Published in Veterinary ophthalmology·2021·Veterinary Medical Center of Long Island, United States·View original on PubMed →
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Original publication title: Effects of 0.02% netarsudil ophthalmic solution on intraocular pressure of normotensive dogs.
- Species:
- dog
Plain-English summary
A group of normotensive Labrador retrievers received a 0.02% netarsudil eye drop solution to see if it could lower their eye pressure. The dogs were treated either once or twice daily, and while the twice-daily treatment showed a slight reduction in eye pressure, it wasn't enough to be considered clinically important. Some dogs experienced mild redness in the eye, but this was temporary and not serious. Overall, the treatment did not significantly help with eye pressure in these healthy dogs, and further research is needed for dogs with glaucoma.
People also search for: dog eye pressure treatment · Labrador retriever eye drops · netarsudil for dogs
Abstract
OBJECTIVES: To evaluate the effect of QD or BID 0.02% netarsudil ophthalmic solution (Aerie Pharmaceuticals) on intraocular pressure (IOP) in normotensive dogs and to describe any adverse effects. ANIMALS STUDIED: Normotensive Labrador retriever dogs were included in this study: 10 received netarsudil in one eye and artificial tears in the contralateral eye QD, and 10 received netarsudil in one eye and artificial tears in the contralateral eye BID. PROCEDURES: Intraocular pressure curves were acquired over a 3-day acclimation period, 5-day dosing period (QD or BID-10 dogs/group), and 3-day recovery period. Toxicity was assessed daily using slit-lamp biomicroscopy and the semiquantitative preclinical ocular toxicology scoring system. RESULTS: Once-daily dosing did not lower IOP over the entire 5-day dosing period (95% CI 0.1 to -0.9 mm Hg, P = .20) or on the last day of dosing (95% CI 0.4 to -0.9 mm Hg, P = .65). Twice-daily dosing resulted in a statistically significant, but clinically unimportant, IOP reduction over the entire 5-day dosing period (-0.6 mm Hg; 95% CI 0.05 to -1.1 mm Hg, P = .02) and on the last day of dosing (-0.9 mm Hg; 95% CI 0.2 to -1.5 mm Hg, P = .003). Adverse events were limited to transient mild-to-moderate conjunctival hyperemia during the dosing phase in eyes receiving netarsudil vs control (P < .0001). CONCLUSIONS: Netarsudil 0.02% ophthalmic solution twice daily resulted in a small, statistically significant, but clinically unimportant, IOP reduction in normotensive dogs. Future studies should investigate efficacy in glaucomatous dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/31908139/