Peer-reviewed veterinary case report
How 5% sodium chloride eye ointment affects normal dog corneas
By Samuel, Michelle et al.·Published in Veterinary ophthalmology·2019·Eye Care for Animals, United States·View original on PubMed →
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Original publication title: Effects of 5% sodium chloride ophthalmic ointment on thickness and morphology of the normal canine cornea.
- Species:
- dog
Plain-English summary
Five healthy Beagle dogs were treated with a 5% sodium chloride eye ointment to see how it affected their corneas. After treatment, the corneas were found to be slightly thinner, but there were no harmful effects on the eye's structure or health. Interestingly, the number of surface cells on the cornea increased with the sodium chloride treatment, while the artificial tears did not have the same effect. Overall, the sodium chloride ointment was safe and showed some positive changes in the cornea's surface cells without causing any damage.
People also search for: dog eye treatment sodium chloride · Beagle cornea thickness · dog eye ointment effects
Abstract
OBJECTIVE: To determine the effect of 5% sodium chloride ophthalmic ointment (5% NaCl) on thickness and morphology of the normal canine cornea using ultrasonic pachymetry (USP), in vivo confocal microscopy (IVCM), and Fourier-domain optical coherence tomography (FD-OCT). METHODS: Five healthy laboratory Beagles received ophthalmic examinations including USP, IVCM, and FD-OCT prior to and at fixed intervals following treatment. The right and left eyes were treated with 5% NaCl and artificial tears ophthalmic ointment (AT), respectively, every 2 hours for 4 treatments/d (days 2-9), and then hourly for 7 treatments/d (day 10). Treatment groups were statistically compared using mixed-effects linear regression. RESULTS: Treatment with 5% NaCl resulted in a 12 μm decrease in corneal thickness from baseline (P < .001), while there was no significant difference in corneal thickness between values obtained at baseline and following treatment with AT (P = .82). Epithelial cell density significantly increased from baseline (530 ± 52 cells/mm) to 577 ± 43 and 567 ± 15 cells/mmwith 5% NaCl and AT, respectively (P = .003 and .005, respectively). However, keratocyte cell density in the anterior and posterior stroma and endothelial cell density did not significantly differ following treatment with 5% NaCl or AT ointment (P > .05). CONCLUSIONS: Short-term topical treatment with 5% NaCl decreased corneal thickness in normal dogs with no observable changes in corneal morphology or signs of ocular toxicity.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/29927055/