Peer-reviewed veterinary case report
Effects of a novel tripeptide on neurological outcomes after spinal cord injury.
- Journal:
- Neuroreport
- Year:
- 2006
- Authors:
- John, Sunil M et al.
- Affiliation:
- Robarts Research Institute · United Kingdom
- Species:
- rodent
Abstract
A biologically active tripeptide [phenylalanine glutamate glycine (feG)] derived from the submandibular gland has anti-inflammatory actions. We have shown that intravenous treatment with feG after spinal cord injury decreases the intraspinal infiltration of leukocytes and associated oxidative damage within 72 h after injury. The present study assessed effects of this treatment on chronic neurological outcomes after clip-compression spinal cord injury at the 12th thoracic segment. Locomotor scores of feG-treated rats were significantly higher than those of controls at 7 weeks after spinal cord injury. Treated rats had significantly less hind paw mechanical allodynia than controls at this time. In conclusion, the anti-inflammatory and anti-oxidative actions of feG treatment correlate with improved neurological outcomes after spinal cord injury.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17164666/