Peer-reviewed veterinary case report
Intranasal vaccine reduces herpesvirus signs and shedding in kittens
By Lappin, Michael R et al.·Published in Journal of Feline Medicine and Surgery·2006·Department of Clinical Sciences, Colorado State University, College of Veterinary Medicine and Biomedical Sciences, Fort Collins, CO 80523-1678, USA, United States·View original on Crossref →
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Original publication title: Effects of a single dose of an intranasal feline herpesvirus 1, calicivirus, and panleukopenia vaccine on clinical signs and virus shedding after challenge with virulent feline herpesvirus 1
- Species:
- cat
Plain-English summary
Ten unvaccinated kittens were given a single dose of an intranasal vaccine to protect against feline herpesvirus 1 (FHV-1), calicivirus, and panleukopenia just before being exposed to the virus. The vaccinated kittens showed fewer signs of illness and lower body temperatures compared to those that did not receive the vaccine. Specifically, those vaccinated 6 or 4 days before exposure had significantly better outcomes. This suggests that giving the vaccine shortly before potential exposure can help reduce the severity of symptoms and the amount of virus shed.
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Abstract
The objective of this study was to determine whether intranasal administration of a commercially available FVRCP vaccine to kittens lessened clinical signs and feline herpesvirus 1 (FHV-1) viral shedding when compared to unvaccinated control kittens after FHV-1 challenge. Three groups of 10 unvaccinated kittens were administered one dose of vaccine 6 days (group 1), 4 days (group 2), or 2 days (group 3) before challenge, respectively. One group was maintained as unvaccinated controls (group 4). FHV-1 challenge was then induced and the kittens were observed for 14 days. When the grouped vaccinated kitten results (groups 1–3) were compared to group 4 results, clinical scores following challenge were significantly lower ( P<0.05) and significantly lower body temperatures ( P<0.05) were detected on days 0, 5 and 9 post-challenge. When evaluated by individual group, group 1 and group 2 kittens had significantly lower clinical scores ( P<0.05) than group 4 kittens post-challenge. In addition, FHV-1 shedding was lower in group 1 kittens when compared to group 4 kittens on day 6 after challenge ( P<0.05). Administration of this vaccine within several days prior to exposure lessened clinical signs of disease and FHV-1 shedding compared to unvaccinated kittens.
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Search related cases →Original publication on Crossref: https://doi.org/10.1016/j.jfms.2005.12.001