Peer-reviewed veterinary case report
How a special diet changes urine in cats with calcium oxalate bladder
By Lulich, Jody P et al.·Published in American journal of veterinary research·2012·College of Veterinary Medicine, United States·View original on PubMed →
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Original publication title: Effects of a urolith prevention diet on urine compositions of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats with calcium oxalate urolithiasis.
- Species:
- cat
Plain-English summary
Ten cats with calcium oxalate stones in their urinary tract were fed a special diet designed to prevent these stones for eight weeks. During this time, their urine was tested, and it was found that the diet significantly increased the levels of glycosaminoglycans, which help prevent the growth of calcium oxalate crystals. However, the diet did not change the levels of other substances in the urine that are also involved in stone formation. This suggests that the urolith prevention diet may be effective in helping to manage or prevent calcium oxalate stones in cats.
People also search for: cat calcium oxalate stones diet · how to prevent cat urinary stones · glycosaminoglycans for cats
Abstract
OBJECTIVE: To evaluate urine concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and nephrocalcin in cats fed a diet formulated to prevent calcium oxalate uroliths. ANIMALS: 10 cats with calcium oxalate urolithiasis. PROCEDURES: In a previous study conducted in accordance with a balanced crossover design, cats were sequentially fed 2 diets (the diet each cat was consuming prior to urolith detection and a diet formulated to prevent calcium oxalate uroliths). Each diet was fed for 8 weeks. At the end of each 8-week period, a 72-hour urine sample was collected. Concentrations of glycosaminoglycans, Tamm-Horsfall glycoprotein, and the 4 isoforms of nephrocalcin in urine samples collected during that previous study were measured in the study reported here. RESULTS; Diet had no effect on the quantity of Tamm-Horsfall glycoprotein and nephrocalcin in urine. However, the urine concentration of glycosaminoglycans was significantly higher during consumption of the urolith prevention diet. CONCLUSIONS AND CLINICAL RELEVANCE: Feeding a urolith prevention diet increased the urine concentration of glycosaminoglycans, which are glycoprotein inhibitors of growth and aggregation of calcium oxalate crystals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/22369540/