Peer-reviewed veterinary case report
Hip osteoarthritis in dogs treated with fat stem cells and platelet
By Upchurch, David A et al.·Published in American journal of veterinary research·2016·View original on PubMed →
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Original publication title: Effects of administration of adipose-derived stromal vascular fraction and platelet-rich plasma to dogs with osteoarthritis of the hip joints.
- Species:
- dog
Plain-English summary
A group of dogs with hip osteoarthritis, which caused lameness and discomfort, received a treatment combining fat-derived cells and platelet-rich plasma (PRP) through injections. After 24 weeks, the dogs that received this treatment showed less pain and improved movement compared to those that received a placebo. The treated dogs had better scores on pain assessments and were less likely to show lameness during exams. This suggests that the combination of fat-derived cells and PRP can help improve mobility and reduce pain in dogs suffering from hip arthritis.
People also search for: dog hip arthritis treatment · platelet-rich plasma for dogs · osteoarthritis in dogs symptoms
Abstract
OBJECTIVE To evaluate effects of simultaneous intra-articular and IV injection of autologous adipose-derived stromal vascular fraction (SVF) and platelet-rich plasma (PRP) to dogs with osteoarthritis of the hip joints. ANIMALS 22 client-owned dogs (12 placebo-treated [control] dogs and 10 treated dogs). PROCEDURES Dogs with osteoarthritis of the hip joints that caused signs of lameness or discomfort were characterized on the basis of results of orthopedic examination, goniometry, lameness score, the Canine Brief Pain Inventory (CBPI), a visual analogue scale, and results obtained by use of a pressure-sensing walkway at week 0 (baseline). Dogs received a simultaneous intraarticular and IV injection of SVF and PRP or a placebo. Dogs were examined again 4, 8, 12, and 24 weeks after injection. RESULTS CBPI scores were significantly lower for the treatment group at week 24, compared with scores for the control group. Mean visual analogue scale score for the treatment group was significantly higher at week 0 than at weeks 4, 8, or 24. Dogs with baseline peak vertical force (PVF) in the lowest 25th percentile were compared, and the treatment group had a significantly higher PVF than did the control group. After the SVF-PRP injection, fewer dogs in the treated group than in the control group had lameness confirmed during examination. CONCLUSIONS AND CLINICAL RELEVANCE For dogs with osteoarthritis of the hip joints treated with SVF and PRP, improvements in CBPI and PVF were evident at some time points, compared with results for the control group.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/27580105/