Peer-reviewed veterinary case report
Effects of aging on hyperalgesia and spinal dynorphin expression in rats with peripheral inflammation.
- Journal:
- Brain research
- Year:
- 2004
- Authors:
- Zhang, Rui-Xin et al.
- Affiliation:
- James Kernan Hospital Mansion · United States
- Species:
- rodent
Abstract
The aging process is associated with various morphological and biochemical changes in the nervous system that may affect the processing of noxious inputs. This study showed greater hyperalgesia and up-regulation of spinal dynorphin (DYN) expression in aging than in young adult rats during CFA-induced peripheral inflammation. These data indicate that nociception is regulated differently in aging individuals, a fact that should be considered when selecting treatment strategies for aging populations with persistent pain.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/14746931/