Peer-reviewed veterinary case report
Effects of alpha-MSH on corneal epithelial lesions in rats.
- Journal:
- Collegium antropologicum
- Year:
- 2012
- Authors:
- Pavan, Josip et al.
- Affiliation:
- University of Zagreb
- Species:
- rodent
Abstract
We investigated the influence of alpha-melanocyte stimulating hormone (alpha-MSH) on the healing of corneal epithelial lesions in male Wistar rats. The lesions were induced by abrading corneal epithelium with a surgical lancet under a biomicroscope. Before the abrasion corneal epithelium was softened with 40% ethanol. alpha-MSH drops in a concentration of 1 x 10(-4) mg/mL significantly promoted epithelial healing, when compared to the control group treated with 0.9% NaCl. Significant reduction of ocular irritation was also observed. Topical alpha-MSH medication could promote the healing of corneal wounds and reduce local inflammatory response without the major side effects of the corticosteroid therapy.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23390842/