Peer-reviewed veterinary case report
Effects of alpha1- and alpha2-adrenoreceptor antagonists on cold allodynia in a rat tail model of neuropathic pain.
- Journal:
- Brain research
- Year:
- 2005
- Authors:
- Kim, Sun Kwang et al.
- Affiliation:
- Department of East-West Medicine · South Korea
- Species:
- rodent
Abstract
Systemic administrations (0.1, 0.5, and 2 mg/kg) of alpha1-adrenoreceptor (AR) antagonist prazosin dose-dependently attenuated cold allodynia in a rat tail model of neuropathic pain, whereas alpha2-AR antagonist yohimbine exacerbated it. These results suggest that the functions of alpha1- and alpha2-AR in this model are excitatory and inhibitory, respectively, consistent with their general properties. It is also proposed that cold allodynia can be reversed by alpha1-AR antagonist and exacerbated by alpha2-AR antagonist.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/15781064/