Peer-reviewed veterinary case report
Ampicillin/sulbactam and enrofloxacin do not change blood pressure
By Moorer, Jeremiah D et al.·Published in Journal of the American Animal Hospital Association·2013·Department of Small Animal Surgery, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Effects of ampicillin/sulbactam and enrofloxacin on the blood pressure of isoflurane anesthetized dogs.
- Species:
- dog
Plain-English summary
A group of healthy dogs under anesthesia were given either enrofloxacin or ampicillin/sulbactam to see how these medications affected their blood pressure. The study found that neither medication caused low blood pressure during the anesthesia, which is good news for pet owners concerned about the safety of these treatments. The dogs' blood pressure remained stable throughout the study, and there were no significant changes in their vital signs. This suggests that both medications can be safely used in dogs undergoing anesthesia without affecting their blood pressure.
People also search for: dog anesthesia safety · enrofloxacin side effects in dogs · ampicillin sulbactam for dogs
Abstract
A blinded, prospective, randomized crossover study was performed to determine the effects of ampicillin Na/sulbactam Na and enrofloxacin on the blood pressure (BP) of healthy anesthetized dogs. Eight dogs were anesthetized three different times. They randomly received enrofloxacin, ampicillin Na/sulbactam Na, and saline. Systolic, diastolic, and mean arterial BPs (SAP, DAP, and MAP, respectively), heart rate (HR), O2 saturation of hemoglobin, end-tidal CO2 (ETCO2) concentration, inspired isoflurane concentration, end-tidal isoflurane (ETiso) concentration, respiratory rate, electrocardiogram, and body temperature were measured for 20 min prior to administration of treatment, during administration over 30 min, and for 30 min after administration. There was no significant difference in the SAP or ETiso. There was no significant change in the arterial pressure values over time in the enrofloxacin and ampicillin Na/sulbactam Na groups. The control group's MAP increased over time and was increased compared with the enrofloxacin group at times 25, 35, 45, and 55. The statistical difference between the enrofloxacin and the control groups was due to an increase in the MAP in the control group, not a decrease in the enrofloxacin group's BP. Neither enrofloxacin nor ampicillin Na/sulbactam Na caused hypotension in healthy dogs anesthetized with isoflurane and fentanyl.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/23861268/