Peer-reviewed veterinary case report
Chloride-free vs Ringer's lactate fluids for dog metabolic acidosis
By Rabozzi, Roberto & Oricco, Stefano·Published in Journal of veterinary internal medicine·2025·Policlinico Veterinario Roma Sud, Italy·View original on PubMed →
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Original publication title: Effects of an Iso-Osmotic Chloride-Free Solution With High Strong Ion Difference vs. Ringer's Lactate on Non-Lactate Metabolic Acidosis in Dogs.
- Species:
- dog
Plain-English summary
A group of 46 dogs suffering from metabolic acidosis (a condition where the body produces too much acid) were treated with either a new chloride-free solution or Ringer's lactate, a common IV fluid. The new solution showed a significant improvement in the dogs' acid-base balance compared to Ringer's lactate, especially at higher infusion rates. The dogs receiving the new solution experienced better results without any major side effects. This suggests that the chloride-free solution could be a safer and more effective treatment option for dogs with this condition.
People also search for: dog metabolic acidosis treatment · Ringer's lactate for dogs · chloride-free IV solution for dogs
Abstract
BACKGROUND: Metabolic acidosis is a common acid-base disorder in critically ill dogs, with fluid therapy being a key but debated treatment. Sodium bicarbonate's risks have spurred interest in safer alternatives such as sodium lactate. OBJECTIVES: To compare the efficacy of a chloride-free, high strong ion difference solution (H-SID) to Ringer's lactate (RL) for treating metabolic acidosis, hypothesizing the superiority of the H-SID solution. ANIMALS: Forty-six dogs with metabolic acidosis from two veterinary hospitals. METHODS: Prospective randomized multicenter study. Dogs were randomly assigned to receive either RL or H-SID at infusion rates of 4 or 10 mL/kg/h for 4 h, based on their volume status. H-SID was compounded with sodium (145 mmol/L), lactate (145 mmol/L), potassium (10 mmol/L), and aspartate (10 mmol/L) in sterile water for injection. RESULTS: The H-SID group showed a significant increase in BE-ecf (mmol/L) at infusion rates of 4 mL/kg/h (p < 0.001) and 10 mL/kg/h (p < 0.001) when compared to the RL group. At the lower infusion rate, the median increase was 4.1 mmol/L (95% CI: 3.37, 6.71), whereas the RL group exhibited a variation of -0.1 (95% CI: -0.75, 2.2). At the higher infusion rate, the median increase was 11 mmol/L (95% CI: 8.16, 12.52) compared to the RL group variation of 1.3 (95% CI: 0.01, 2.96). CONCLUSIONS AND CLINICAL IMPORTANCE: Our results indicate a significant alkalizing effect of the H-SID solution in dogs with non-lactic metabolic acidosis, demonstrating a superior effect compared to the RL solution without notable adverse effects.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/40235194/