Peer-reviewed veterinary case report
Dog knee cartilage and bone defect treated with stem cell gel
By Yamazoe, Kazuaki et al.·Published in The Journal of veterinary medical science·2007·Department of Veterinary Medicine, Japan·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Effects of atelocollagen gel containing bone marrow-derived stromal cells on repair of osteochondral defect in a dog.
- Species:
- dog
Plain-English summary
A dog with a joint injury that caused an osteochondral defect (a type of cartilage damage) received a treatment involving a special gel containing its own bone marrow-derived stem cells. While the cartilage didn't show signs of early healing, the underlying bone began to regenerate significantly within two weeks. The stem cells appeared to move deeper into the defect, likely due to increased pressure from inflammation after the surgery. This suggests that using stem cells could help with bone repair in similar cases, even if cartilage healing takes longer.
People also search for: dog joint injury treatment · stem cells for dog cartilage repair · osteochondral defect in dogs · dog bone regeneration therapy
Abstract
To clarify the contribution of autologous transplantation of mesenchymal stromal cells (MSCs), an atelocollagen gel containing or not containing fluorescently-labeled canine MSCs was transplanted into an osteochondral defect which did not repair spontaneously and the histological repair of the defect was compared. Although an early repair of the cartilage was not observed in either defect, the reproduction of subchondral bone was remarkable in the MSCs-implanted defect. Moreover, in 2 weeks after operation, the implanted MSCs were located in the deeper regions of the defect, suggesting the differentiation of osteoblasts. There was a possibility that the movement of the implanted MSCs was due to an increase in intra-articular pressure from postoperative inflammation.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17827891/