Peer-reviewed veterinary case report
Calcitriol and seocalcitol slow growth of dog bladder cancer cells
By Kaewsakhorn, Thattawan et al.·Published in Anticancer research·2005·Department of Veterinary Biosciences, United States·View original on PubMed →
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Original publication title: Effects of calcitriol, seocalcitol, and medium-chain triglyceride on a canine transitional cell carcinoma cell line.
- Species:
- dog
Plain-English summary
A study looked at how two forms of vitamin D, calcitriol and seocalcitol, combined with medium-chain triglyceride (MCT), could help treat bladder cancer (transitional cell carcinoma) in dogs. The researchers found that these treatments slowed the growth of cancer cells and caused them to stop dividing. MCT made the effects of the vitamin D treatments even stronger. This suggests that using calcitriol and seocalcitol along with MCT could be a promising option for managing bladder cancer in dogs.
People also search for: dog bladder cancer treatment · calcitriol for dogs cancer · seocalcitol and MCT for canine TCC
Abstract
BACKGROUND: Transitional cell carcinoma (TCC) in dogs is associated with high morbidity and mortality. Calcitriol and its analog seocalcitol, combined with medium-chain triglyceride (MCT), have potential for the treatment of this disease. MATERIALS AND METHODS: TCC cells were treated with calcitriol or seocalcitol, alone or combined with MCT. Cell growth, cell cycle kinetics, vitamin D receptor (VDR) localization and expression, and Bcl-2 expression were measured. RESULTS: Canine TCC expresses high levels of nuclear VDR. Furthermore, calcitriol and seocalcitol significantly inhibited cell growth and calcitriol caused G0/G1 cell cycle arrest. Bcl-2 expression was slightly decreased in cells treated with these compounds, although no significant changes in VDR expression were observed. MCT enhanced the growth inhibitory effect of both compounds. CONCLUSION: Calcitriol and seocalcitol inhibited TCC cell growth via induction of cell cycle arrest and MCT enhanced this effect. Therefore, calcitriol and seocalcitol with MCT may have therapeutic potential for canine bladder cancer.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16080513/