Peer-reviewed veterinary case report
How carprofen and morphine lower isoflurane needs in dogs
By Ko, Jeff C H et al.·Published in Journal of the American Animal Hospital Association·2009·Department of Veterinary Clinical Sciences, United States·View original on PubMed →
PetCaseFinder translated the abstract of this peer-reviewed paper into plain English so pet owners can read it. We do not publish original research — every detail traces back to the citation above. How we work →
Original publication title: Effects of carprofen and morphine on the minimum alveolar concentration of isoflurane in dogs.
- Species:
- dog
Plain-English summary
A group of eight healthy adult dogs was given either morphine, carprofen, or a combination of both before undergoing anesthesia with isoflurane. The results showed that morphine alone or with carprofen allowed for a lower dose of isoflurane to be used compared to dogs that received no medication. This means that using morphine can help reduce the amount of anesthesia needed, which is beneficial for the dogs during surgery. The study suggests that combining these medications can enhance their effects, making anesthesia safer and more effective for dogs.
People also search for: dog anesthesia options · morphine for dogs · carprofen and isoflurane in dogs
Abstract
The minimum alveolar concentration (MAC) of isoflurane in dogs was determined following carprofen (2.2 mg/kg per os) alone, morphine (1 mg/kg intravenously) alone, carprofen and morphine, and no drug control in eight healthy adult dogs. Isoflurane MAC following administration of morphine alone (0.81%+/-0.18%) or carprofen and morphine (0.68%+/-0.31%) was significantly less than the control MAC (1.24%+/-0.15%). Isoflurane MAC after carprofen alone (1.13%+/-0.13%) was not significantly different from the control value. Results indicated that administration of morphine alone or in combination with carprofen significantly reduced the MAC of isoflurane in dogs. The isoflurane MAC reduction was additive between the effects of carprofen and morphine.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19122060/