Peer-reviewed veterinary case report
Clomipramine reduces urine marking in cats after 4 weeks
By Landsberg, Gary M & Wilson, Andrea L·Published in Journal of the American Animal Hospital Association·2005·Doncaster Animal Clinic, Canada·View original on PubMed →
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Original publication title: Effects of clomipramine on cats presented for urine marking.
- Species:
- cat
Plain-English summary
A group of 25 cats that were urinating inappropriately by spraying urine at least four times a week were treated with clomipramine, a medication that helps with behavior issues. After four weeks, 20 of the cats showed a significant decrease in spraying, with many reducing their episodes by 75% or more. The side effects were mild, and most cats continued to need medication for several months afterward, often at a lower dose. This treatment helped many cats and their owners manage this frustrating behavior.
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Abstract
Twenty-five cats exhibiting at least four episodes of vertical urine marking per week were assessed. Following a medical workup, a 4-week clomipramine trial was instituted, using a mean dose of 0.54 mg/kg per os q 24 hours. No concurrent behavioral or environmental modifications were applied. There was a statistically significant (P<0.0001) decrease in urine spraying when the cats were on clomipramine, with 20 of 25 cats having a > or =75% reduction in spraying within 4 weeks. Side effects were mild. Twenty cats were followed for an additional 5 months. Fifteen cats required medication to control the spraying, often at a reduced dose.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15634861/