Peer-reviewed veterinary case report
Compound Dan-shen Root Pill improves blood flow in dogs with high-fat
By Guo, Jun et al.·Published in Clinical hemorheology and microcirculation·2005·Department of Biophysics, China·View original on PubMed →
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Original publication title: Effects of Compound Dan-shen Root Dropping Pill on hemorheology in high-fat diet induced hyperlipidemia in dogs.
- Species:
- dog
Plain-English summary
A group of dogs on a high-fat diet developed high cholesterol and triglycerides, leading to hyperlipidemia. Six of these dogs were given a herbal supplement called Compound Dan-shen Root Dropping Pill (CDRDP) while continuing their diet. After four months, blood tests showed that the dogs taking CDRDP had lower cholesterol and triglyceride levels, and their blood flow improved. This suggests that CDRDP can help manage high cholesterol in dogs.
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Abstract
The purpose of this study was to examine the effects of Compound Dan-shen Root Dropping Pill (CDRDP) (Tasly Group, Tianjing, China) on hemorheology and biorheology of dogs suffering from hyperlipidemia induced by high-fat diet. Eighteen dogs were randomly divided into two groups: the high-fat diet group (H group); the control group (C group), fed with a standard laboratory diet. Six month later, six dogs in the H group were chosen as the drug-taking group (D group), to which CDRDP was administered, fed with the same diet as H group. In the 4th month, blood was taken from the veins of the dogs, and blood triglyceride (TG), total cholesterol (TC), RBC hemorheological indexes as well as malondialdehyde (MDA), glutathione transferase (GSH-ST) and superoxide dismutase (SOD) activities in plasma and erythrocytes were measured. Compared with H group, TC, TG, plasma MDA levels, the whole blood viscosity, RBC osmotic fragility and the value of CHOL (cholesterol)/PL (phospholipid) of the membrane of D group decreased, however, erythrocyte GSH-ST, histopathological changes in liver, deformation index (DI), orientation index (DI)or, small deformation index (DI)d, electrophoresis ratio and microfluidity of the membrane lipid bilayer of RBCs, increased distinctly. CDRDP can improve micro-hemorheological characteristics, therefore has a significant therapy application of hyperlipidemia.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15665423/