Peer-reviewed veterinary case report
Bone healing in beagle dog gum defects improved by FGF-2 with beta-TCP
By Anzai, Jun et al.·Published in Biochemical and biophysical research communications·2010·Pharmacology Department, Japan·View original on PubMed →
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Original publication title: Effects of concomitant use of fibroblast growth factor (FGF)-2 with beta-tricalcium phosphate (β-TCP) on the beagle dog 1-wall periodontal defect model.
- Species:
- dog
Plain-English summary
A group of beagle dogs with periodontal disease had bone defects around their teeth treated with either a combination of fibroblast growth factor-2 (FGF-2) and beta-tricalcium phosphate (β-TCP) or β-TCP alone. After six weeks, the dogs treated with FGF-2 showed significantly more bone regeneration and healthier periodontal tissue compared to those who only received β-TCP. There were no signs of inflammation or other complications in either treatment group. This suggests that using FGF-2 alongside β-TCP can effectively help restore bone and tissue in dogs suffering from severe gum disease.
People also search for: beagle periodontal disease treatment · FGF-2 for dog gum disease · beta-tricalcium phosphate for dogs
Abstract
The effects of concomitant use of fibroblast growth factor-2 (FGF-2) and beta-tricalcium phosphate (β-TCP) on periodontal regeneration were investigated in the beagle dog 1-wall periodontal defect model. One-wall periodontal defects were created in the mesial portion of both sides of the mandibular first molars, and 0.3% FGF-2 plus β-TCP or β-TCP alone was administered. Radiographic evaluation was performed at 0, 3, and 6 weeks. At 6 weeks, the periodontium with the defect site was removed and histologically analyzed. Radiographic findings showed that co-administration of FGF-2 significantly increased bone mineral contents of the defect sites compared with β-TCP alone. Histologic analysis revealed that the length of the regenerated periodontal ligament, the cementum, distance to the junctional epithelium, new bone height, and area of newly formed bone were significantly increased in the FGF-2 group. No abnormal inflammatory response or ankylosis was observed in either group. These findings indicate the efficacy of concomitant use of FGF-2 and β-TCP as an osteoconductive material for periodontal regeneration following severe destruction by progressive periodontitis.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21078294/