Peer-reviewed veterinary case report
Cyclosporine A improves skin symptoms in dogs with sebaceous adenitis
By Linek, Monika et al.·Published in Journal of the American Veterinary Medical Association·2005·Veterinary Clinic Linek, Germany·View original on PubMed →
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Original publication title: Effects of cyclosporine A on clinical and histologic abnormalities in dogs with sebaceous adenitis.
- Species:
- dog
Plain-English summary
A group of 12 dogs with sebaceous adenitis, a skin condition that causes hair loss and inflammation, were treated with cyclosporine A for a year. After just four months, the dogs showed significant improvement in their symptoms, including less hair loss and reduced inflammation in their skin. The treatment helped regenerate the sebaceous glands, which are important for healthy skin. However, the symptoms returned when the medication was stopped, indicating that ongoing treatment is necessary to keep the condition under control.
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Abstract
OBJECTIVE: To evaluate the effects of cyclosporine A in the treatment of sebaceous adenitis in dogs. DESIGN: Open-label clinical trial. ANIMALS: 12 dogs with sebaceous adenitis. PROCEDURE: Dogs were treated with cyclosporine A at a dosage of 5 mg/kg/d (2.3 mg/lb/d), PO, for 12 months and reevaluated every 4 months. A clinical score was calculated by grading the extent of alopecia and severity of follicular casts as absent, mild, moderate, or severe in each of 17 body regions. Biopsy specimens were obtained and examined histologically and by means of immunohistochemical staining. RESULTS: Mean clinical score was significantly decreased, compared with baseline score, after 4 months of treatment and remained low after 8 and 12 months. Histologically, the severity of inflammation was significantly decreased, as were numbers of macrophages, CD3+ T cells, and major histocompatibility complex class II-expressing cells. The percentage of hair follicles with sebaceous glands increased, suggesting regeneration of sebaceous glands. Clinical signs recurred when cyclosporine administration was discontinued. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that administration of cyclosporine A at a dosage of 5 mg/kg/d may reduce the inflammation associated with sebaceous adenitis in dogs. Long-term treatment appears to be neccessary to control the disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15646573/