Peer-reviewed veterinary case report
Safety of high-dose imidacloprid-ivermectin on sensitive Collies
By Paul, Allan J et al.·Published in American journal of veterinary research·2004·Department of Veterinary Pathobiology, United States·View original on PubMed →
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Original publication title: Effects of dermal application of 10.0% imidacloprid-0.08% ivermectin in ivermectin-sensitive Collies.
- Species:
- dog
Plain-English summary
Fifteen Collies known to be sensitive to ivermectin were tested for safety after receiving a topical treatment containing imidacloprid and ivermectin at higher than usual doses. The dogs were closely monitored for any signs of toxicity, such as lethargy or abnormal behavior, but none showed any negative effects during the study. This suggests that the topical treatment is safe for ivermectin-sensitive Collies, even at doses three to five times higher than typically recommended.
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Abstract
OBJECTIVE: To evaluate the safety of dermal application of 10.0% imidacloprid-0.08% ivermectin in ivermectin-sensitive Collies at dose rates of 3 to 5 times the proposed maximum therapeutic dose. ANIMALS: 15 Collies (5 males and 10 females) that were confirmed as ivermectin-sensitive dogs. PROCEDURE: Dogs were assigned to 3 treatment groups (control, 3X, or 5X group) in a randomized block design on the basis of the maximal ivermectin-sensitivity score obtained during preliminary screening. Dogs in groups 3X and 5X were treated at 3 and 5 times the maximum label dose, respectively. Control dogs received an application of an equal volume of a nonmedicated solution. Observation and scoring on all days were conducted to specifically include neurologic signs typical of ivermectin toxicosis, including lethargy, ataxia, abnormal mydriasis, and abnormal salivation. RESULTS: None of the dogs had clinical abnormalities during the study period. CONCLUSIONS AND CLINICAL RELEVANCE: Analysis of results of this study indicates that dermal application of 10.0% imidacloprid-0.08% ivermectin is safe for use in ivermectin-sensitive Collies at dose rates of 3 or 5 times the proposed maximum therapeutic dose.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/15027671/