Peer-reviewed veterinary case report
How diazepam or lidocaine affect propofol dose and heart in dogs
By Braun, Christina et al.·Published in Journal of the American Animal Hospital Association·2007·Department of Large Animal Medicine, United States·View original on PubMed →
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Original publication title: Effects of diazepam or lidocaine premedication on propofol induction and cardiovascular parameters in dogs.
- Species:
- dog
Plain-English summary
A group of dogs was given either diazepam or lidocaine before being put under anesthesia with propofol to see how it affected their heart rates and blood pressure. The study found that neither medication significantly changed the amount of propofol needed for anesthesia or the dogs' cardiovascular responses. This means that both diazepam and lidocaine can be safely used as premedications without affecting how well the dogs respond to anesthesia.
People also search for: dog anesthesia safety · diazepam for dogs before surgery · lidocaine premedication in dogs
Abstract
The effects of diazepam or lidocaine on the propofol induction dose and certain cardiovascular parameters were documented in this randomized, blinded study. Dogs received 0.9% saline (0.1 mL/kg intravenously [i.v.]), lidocaine (2 mg/kg i.v.), or diazepam (0.25 mg/kg i.v.) prior to propofol i.v. until loss of jaw tone was achieved (up to a maximum of 8 mg/kg). Propofol was followed by 0.3 mg/kg atracurium i.v. Direct arterial blood pressures and heart rates were recorded before premedication, induction, and intubation. No statistically significant differences were found among the groups for cardiovascular measurements or for the propofol dose required for intubation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/17209079/