Peer-reviewed veterinary case report
Calcium fructoborate supplements improve joint comfort in dogs
By Price, A K et al.·Published in Journal of animal science·2017·View original on PubMed →
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Original publication title: Effects of dietary calcium fructoborate supplementation on joint comfort and flexibility and serum inflammatory markers in dogs with osteoarthritis.
- Species:
- dog
Plain-English summary
A group of dogs with osteoarthritis were given either a placebo or calcium fructoborate (CFB) supplements to see if it helped with their joint pain and movement. After 28 days, dogs receiving the low and high doses of CFB showed improved ability to get up from lying down compared to those on the placebo. Larger dogs on the low dose also reported less pain and were better at rising than those who didn't receive the supplement. Overall, CFB was well-tolerated and may help reduce joint discomfort in dogs.
People also search for: dog osteoarthritis treatment · calcium fructoborate for dogs · joint pain relief for large dogs
Abstract
Our objective was to evaluate the short-term effects of calcium fructoborate (CFB) on gait, joint range of motion, serum inflammatory markers, and owner perception of pain in client-owned dogs. We used 59 osteoarthritic dogs with impairment, with dogs being randomly assigned to 4 treatments: placebo (60 mg fructose; = 15), low dose (69 mg CFB; = 14), high dose (127 mg CFB; = 14), or combination (69 mg CFB, 500 mg glucosamine hydrochloride and 200 mg chondroitin sulfate; = 16). Dogs up to 22.9 kg received 1 capsule/d, while dogs weighing 23 to 50 kg received 2 capsules/d. A physical examination, radiographs, goniometry measurements, gait analysis, blood sample collection, and a canine brief pain inventory questionnaire were performed on d 0 and 28. Change from baseline values were statistically analyzed among groups. After 28 d, dogs fed the low and high doses had an improved ( < 0.05) ability to rise from a lying position compared to placebo. Dogs fed the high dose also had a greater ( = 0.05) increase in soluble receptor for advanced glycation end products concentration than dogs fed the placebo. Sub-analysis of only large dogs (> 23 kg) showed that dogs fed the low dose had decreased ( < 0.05) pain severity score and pain at its worst compared to dogs fed the placebo. Large dogs fed the low dose also were shown to improve ( < 0.05) in their ability to rise from a lying position compared to dogs fed the placebo. Overall, CFB supplementation was well-tolerated and may aid in mitigating joint discomfort in dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28727103/