Effects of dietary glycerol, vitamin C and niacinamide supplementation on liver of growing-finishing pigs.

Abstract

The influence of supplementing glycerol, vitamin C and niacinamide on the liver of growing-finishing pigs has not yet been examined. This study investigated the effect of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide supplementation at single or combination on liver of growing-finishing pigs. Compared with pigs supplemented with 0% glycerol, 0% vitamin C and 0% niacinamide, pigs supplemented only with 10% glycerol had higher (&#x202f;<&#x202f;0.05) TNF-concentration, partially hepatic steatosis, higher (&#x202f;<&#x202f;0.05) relative abundances of,,,,and, lower (&#x202f;<&#x202f;0.05) solute carrier family 7 member 11 () expression in liver tissue. However, pigs offered the diet with a mixture of 0.06% vitamin C and 0.05% niacinamide had higher (&#x202f;<&#x202f;0.05) relative abundance ofand expression of, lower (&#x202f;<&#x202f;0.05) relative abundances ofandin liver tissue. Supplementation of 10% glycerol, 0.06% vitamin C and 0.05% niacinamide simultaneously to pigs increased (&#x202f;<&#x202f;0.05) the ferrous ion level, the relative abundances of,and, the expressions of gene Cryptochrome-1() and, but decreased (&#x202f;<&#x202f;0.05) the expressions of gene C-reactive protein () and galactokinase 1 () in liver tissue. Supplementation with 0.06% vitamin C and 0.05% niacinamide can alleviate the damage in liver of pigs fed a diet containing 10% glycerol.