Peer-reviewed veterinary case report
Effects of Dietary Plant-Origin Glucosylceramide on Bowel Inflammation in DSS-Treated Mice.
- Journal:
- Journal of oleo science
- Year:
- 2015
- Authors:
- Arai, Katsuhito et al.
- Affiliation:
- Department of Food Science
- Species:
- rodent
Abstract
The effects of dietary plant-origin glucosylceramide (GlcCer) on symptoms similar to those of inflammatory bowel diseasewere investigated in dextran sulfate sodium salt (DSS)-treated mice. Dietary GlcCer suppressed decreases in body weight due to DSS administration. To determine its effects on the colon, we examined its surface under a microscope following toluidine blue staining. Dietary GlcCer decreased DSS-induced chorionic crypt injury and elevated myeloperoxidase levels. Moreover, dietary GlcCer significantly suppressed the production of cytokines by the intestinal mucosa. These results provide evidence for the suppression of DSS-induced inflammation by dietary GlcCer.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/26136173/