Peer-reviewed veterinary case report
Enalapril effects on heart thickening in cats with pressure overload
By Ishikawa, Yumi et al.·Published in Journal of feline medicine and surgery·2007·Veterinary Teaching Hospital, Japan·View original on PubMed →
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Original publication title: Effects of enalapril in cats with pressure overload-induced left ventricular hypertrophy.
- Species:
- cat
Plain-English summary
A group of cats with heart issues caused by pressure overload were treated with a medication called enalapril to see if it could help their condition. After four weeks of treatment, the cats showed improvements in heart function and lower blood pressure without any negative effects on their kidney health. The study found that enalapril helped reduce the thickness of the heart walls, which is a sign of better heart health. Overall, enalapril appears to be a beneficial treatment for cats with heart problems related to pressure overload.
People also search for: cat heart problems treatment · enalapril for cats · cat kidney health and heart disease · feline left ventricular hypertrophy symptoms
Abstract
In order to evaluate the effect of enalapril on haemodynamics and renal function in a pressure overload model, we prepared eight feline models of left ventricular hypertrophy (LVH) by banding of the aortic arch. The LVH cats were assigned to the placebo group or the enalapril group (0.5 mg/kg, PO, sid) 3 months following surgery, and each received its respective drug for 4 weeks. Each week, blood pressure, angiotensin converting enzyme (ACE) activity in blood, and creatinine clearance were measured, and complete blood count (CBC), biochemical examination of the blood, echocardiography, and chest radiography were carried out. The interventricular septum thickness (IVSd, IVSs), fractional shortening (FS), and ejection fraction (EF) increased significantly in the LVH cats following surgery (P<0.05). There was no significant difference between the placebo group and the enalapril group with respect to general physical parameters, CBC, biochemical parameters and renal function. In the enalapril group, systolic arterial pressure, mean arterial pressure, and ACE activity in blood decreased significantly following administration (P<0.05). In addition, the left ventricular free wall thickness in diastole and IVSd decreased significantly following administration (P<0.05). These results suggest that, in a pressure overload model, enalapril (0.5 mg/kg, sid) inhibits cardiac hypertrophy, reduces blood pressure, and does not adversely affect renal function.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16934512/