Peer-reviewed veterinary case report
Fluticasone doses tested for treating asthma inflammation in cats
By Cohn, Leah A et al.·Published in Journal of feline medicine and surgery·2010·University of Missouri, United States·View original on PubMed →
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Original publication title: Effects of fluticasone propionate dosage in an experimental model of feline asthma.
- Species:
- cat
Plain-English summary
A group of cats with asthma-like symptoms were treated with an inhaled medication called fluticasone propionate to see how different doses affected their breathing. The study found that all doses helped reduce inflammation in their airways without causing side effects related to hormone levels. The best results were seen with a lower dose of 44 micrograms given twice a day. This suggests that this dosage could be a good option for managing asthma in cats.
People also search for: cat asthma treatment · fluticasone for cats · cat breathing problems medication
Abstract
Cats with inflammatory bronchial disease are usually treated with glucocorticoid (GC) drugs to reduce airway inflammation. Inhalant GC delivery can preserve airway effects while systemic effects are minimized. An appropriate dosage regimen for inhaled GC in cats has not been investigated. A blinded, randomized, cross-over study design was used to investigate the ability of three different dosages of the inhalant GC fluticasone propionate delivered by metered dose inhaler to ameliorate eosinophilic airway inflammation in cats with experimentally induced allergic airway inflammation. Further, suppression of the hypothalamic-pituitary-adrenal axis (HPAA) at each dose was assessed. Fluticasone administered at dosages of 44, 110, or 220 microg q 12h reduced airway eosinophilia by 74%, 82%, or 81%, respectively (no difference). None of the dose regimens tested caused HPAA suppression. We conclude that a twice daily dosage of 44 microg fluticasone should be evaluated for the management of cats with naturally occurring inflammatory bronchial disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/19647461/