Peer-reviewed veterinary case report
Effects of fluticasone propionate dosage in an experimental model of feline asthma.
- Journal:
- Journal of feline medicine and surgery
- Year:
- 2010
- Authors:
- Cohn, Leah A et al.
- Affiliation:
- University of Missouri · United States
- Species:
- cat
Plain-English summary
In this study, researchers looked at how different doses of an inhaled medication called fluticasone propionate could help cats with asthma, which is a type of inflammatory bronchial disease. They tested three doses of the medication to see how well it reduced inflammation in the airways of cats that had been given an allergy to mimic asthma. All three doses worked similarly well to reduce inflammation, and none of them caused any negative effects on the cats' hormone levels. The researchers suggest that using a lower dose of 44 micrograms twice a day could be a good option for treating cats with asthma in real life.
Abstract
Cats with inflammatory bronchial disease are usually treated with glucocorticoid (GC) drugs to reduce airway inflammation. Inhalant GC delivery can preserve airway effects while systemic effects are minimized. An appropriate dosage regimen for inhaled GC in cats has not been investigated. A blinded, randomized, cross-over study design was used to investigate the ability of three different dosages of the inhalant GC fluticasone propionate delivered by metered dose inhaler to ameliorate eosinophilic airway inflammation in cats with experimentally induced allergic airway inflammation. Further, suppression of the hypothalamic-pituitary-adrenal axis (HPAA) at each dose was assessed. Fluticasone administered at dosages of 44, 110, or 220 microg q 12h reduced airway eosinophilia by 74%, 82%, or 81%, respectively (no difference). None of the dose regimens tested caused HPAA suppression. We conclude that a twice daily dosage of 44 microg fluticasone should be evaluated for the management of cats with naturally occurring inflammatory bronchial disease.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/19647461/