Peer-reviewed veterinary case report
Indinavir treatment effects in dogs with stage III splenic
By Spugnini, Enrico P et al.·Published in In vivo (Athens, Greece)·2006·SAFU Department, Italy·View original on PubMed →
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Original publication title: Effects of indinavir in a preliminary phase I study on dogs with stage III slenic hemangiosarcoma.
- Species:
- dog
Plain-English summary
A group of dogs with advanced splenic hemangiosarcoma (a type of cancer) was treated with a drug called Indinavir, which is usually used for HIV. The study aimed to see if this medication could help slow down the cancer's progression and if it had any harmful side effects. The results indicated that Indinavir might be helpful for dogs with small amounts of remaining cancer after surgery. While more research is needed, this could be a promising option for managing this serious condition.
People also search for: dog hemangiosarcoma treatment · Indinavir for dogs cancer · splenic cancer in dogs
Abstract
HIV protease inhibitors are antiretroviral drugs able to prevent production of infectious particles. It has been shown that these protease inhibitors are able to inhibit cancer-promoted angiogenesis in patients affected by Kaposi's sarcoma. A preliminary phase I study on dogs with stage III splenic hemangiosarcoma was designed in order to evaluate the efficacy and toxicity of the protease inhibitor Indinavir to delay the progression of this advanced neoplasm. The results suggest that Indinavir is potentially beneficial in dogs affected by microscopic residual disease.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16433040/