Peer-reviewed veterinary case report
Effects of alfaxalone and dexmedetomidine on eye and heart tests
By Guo, Yizhe et al.·Published in Frontiers in veterinary science·2024·College of Veterinary Medicine, China·View original on PubMed →
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Original publication title: Effects of intramuscular alfaxalone and dexmedetomidine alone and combined on ocular, electroretinographic, and cardiorespiratory parameters in normal cats.
- Species:
- cat
Plain-English summary
Eight healthy female cats were given different sedation treatments to see how they affected their eyes and heart rates during a short eye test. The treatments included a sedative called alfaxalone, another called dexmedetomidine, and a combination of both. After the treatments, the cats showed higher eye pressure and lower tear production, but there were no major differences between the sedation methods. This study helps show that these sedation options can be used safely for eye tests in cats, although more baseline data is needed for better comparisons.
People also search for: cat eye pressure treatment · cat sedation for eye tests · dexmedetomidine effects on cats
Abstract
BACKGROUND: This study aimed to determine the effects of intramuscular (IM) administration of alfaxalone with or without dexmedetomidine on short electroretinography (ERG), ocular parameters and cardiorespiratory in healthy cats. METHODS: Eight healthy female spayed cats were treated with three sedation protocols: IM administration of 5 μg/kg dexmedetomidine (DEX), 5 mg/kg alfaxalone (ALF), and 5 μg/kg dexmedetomidine plus 5 mg/kg alfaxalone (DEX + ALF). The washout period after each treatment was 2 weeks. Physiological parameters, time metrics, intraocular pressure (IOP), Schirmer tear test 1 (STT-1) and a short ERG protocol were recorded. For age data, weight data, time metrics and ERG data, one-way ANOVA with Bonferroni posterior comparisons were performed. For physiological parameters, IOP and STT-1 data, two-way repeated measures ANOVA with Bonferroni posterior comparisons were performed. Statistical significance was set at a-value <0.05. RESULTS: IOPs were increased in all three groups compared to baseline and showed no significant differences among three groups at any time point. STT-1 values were decreased significantly during the process. Significant differences were noticed between a-wave amplitude in the dark-adapted response between DEX and ALF, and a-wave amplitude in light-adapted response between ALF and DEX + ALF. CONCLUSION: This study demonstrates the feasibility of three sedation protocols for short ERG recording in cats. All these treatments resulted in increased IOP values and reduced STT-1 values. But baseline data of ERG was not obtained as a blank control in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/39021405/