Peer-reviewed veterinary case report
How acepromazine and butorphanol affect propofol dose in Beagle dogs
By Dantino, Stephanie C et al.·Published in Veterinary anaesthesia and analgesia·2022·Department of Large Animal Clinical Sciences, United States·View original on PubMed →
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Original publication title: Effects of intravenous acepromazine and butorphanol on propofol dosage for induction of anesthesia in healthy Beagle dogs.
- Species:
- dog
Plain-English summary
A group of healthy Beagle dogs underwent anesthesia to see how different medications affected the amount of propofol needed for intubation. The dogs received either a saline solution, acepromazine, butorphanol, or a combination of both before being given propofol. The results showed that the combination of acepromazine and butorphanol allowed for a significant reduction in the propofol dosage needed, but some dogs experienced low blood pressure and breathing issues during the procedure. This suggests that while the combination can be effective, it also carries some risks that pet owners should discuss with their veterinarian.
People also search for: dog anesthesia propofol dosage · Beagle anesthesia risks · acepromazine butorphanol for dogs
Abstract
OBJECTIVE: To determine the effects of intravenous (IV) premedication with acepromazine, butorphanol or their combination, on the propofol anesthetic induction dosage in dogs. STUDY DESIGN: Prospective, blinded, Latin square design. ANIMALS: A total of three male and three female, healthy Beagle dogs, aged 3.79 ± 0.02 years, weighing 10.6 ± 1.1 kg, mean ± standard deviation. METHODS: Each dog was assigned to one of six IV treatments weekly: 0.9% saline (treatment SAL), low-dose acepromazine (0.02 mg kg; treatment LDA), high-dose acepromazine (0.04 mg kg; treatment HDA), low-dose butorphanol (0.2 mg kg; treatment LDB), high-dose butorphanol (0.4 mg kg; treatment HDB); and a combination of acepromazine (0.02 mg kg) with butorphanol (0.2 mg kg; treatment ABC). Physiologic variables and sedation scores were collected at baseline and 10 minutes after premedication. Then propofol was administered at 1 mg kgIV over 15 seconds, followed by boluses (0.5 mg kgover 5 seconds) every 15 seconds until intubation. Propofol dose, physiologic variables, recovery time, recovery score and adverse effects were monitored and recorded. Data were analyzed using mixed-effects anova (p < 0.05). RESULTS: Propofol dosage was lower in all treatments than in treatment SAL (4.4 ± 0.5 mg kg); the largest decrease was recorded in treatment ABC (1.7 ± 0.3 mg kg). Post induction mean arterial pressures (MAPs) were lower than baseline values of treatments LDA, HDA and ABC. Apnea and hypotension (MAP < 60 mmHg) developed in some dogs in all treatments with the greatest incidence of hypotension in treatment ABC (4/6 dogs). CONCLUSIONS AND CLINICAL RELEVANCE: Although the largest decrease in propofol dosage required for intubation was after IV premedication with acepromazine and butorphanol, hypotension and apnea still occurred.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/35606286/