Peer-reviewed veterinary case report
Radiation balloon treatment to reduce urethral tissue growth
By Shin, Ji Hoon et al.·Published in Acta radiologica (Stockholm, Sweden : 1987)·2006·Department of Radiology and Research Institute of Radiology, South Korea·View original on PubMed →
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Original publication title: Effects of irradiation using a radioisotope-filled balloon on tissue hyperplasia caused by stent placement in a canine urethral model.
- Species:
- dog
Plain-English summary
A group of ten dogs had stents placed in their urethras to treat a blockage, and some of them received a special treatment using a radioactive balloon to help prevent excessive tissue growth (hyperplasia) around the stent. After 12 weeks, the dogs that received the radioactive treatment showed less thickening of the tissue compared to those that only had the standard balloon treatment. While the lower dose of radiation (20 Gy) seemed to work well, there wasn't a big difference between the two radiation doses used. This suggests that the radioactive balloon treatment could be a helpful option for reducing tissue growth after stent placement in dogs.
Abstract
PURPOSE: To evaluate 20 Gy and 40 Gy of intraluminal beta-irradiation using a 188Re-7mercaptoacetyltriglycine (MAG3)-filled balloon catheter to reduce tissue hyperplasia caused by covered stent placement for 12 weeks of follow-up in a canine urethral model. MATERIAL AND METHODS: Ten dogs underwent 188Re-MAG3-filled balloon dilatation immediately after stent placement; 20 Gy at 1-mm tissue depth in group I (n = 5) and 40 Gy in group II (n = 5), whereas 5 dogs (group III) underwent conventional balloon dilatation only. RESULTS: There were no significant differences among the three groups for percentage diameter of stenosis, although this was highest in group III. There was a tendency toward lower mean thickness of the epithelial layer and the papillary projection for out-stent area, and thickness of the papillary projection and degree of inflammatory cells for instent area in groups I and II compared with group III. Thickness of the papillary projection in out-stent area was significantly different among the three groups (P = 0.031). It was significantly less thick in group I than in group III (P < 0.05), whereas group II was not significantly different from group III. CONCLUSION: 188Re-MAG3-filled balloon dilatation has the potential to reduce tissue hyperplasia after 12 weeks of follow-up in a canine urethral model. The use of 20 Gy compared to 40 Gy did not show significant differences.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16739707/