Peer-reviewed veterinary case report
Ivabradine effects on heart rhythm in older dogs with atrial
By Li, Yao-Dong et al.·Published in Medical science monitor : international medical journal of experimental and clinical research·2015·Department of Pacing and Electrophysiology, China·View original on PubMed →
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Original publication title: Effects of ivabradine on cardiac electrophysiology in dogs with age-related atrial fibrillation.
- Species:
- dog
Plain-English summary
A group of aging dogs, aged 8 to 10 years, with age-related atrial fibrillation (AF) were treated with a medication called Ivabradine to see if it could help manage their heart condition. The results showed that Ivabradine significantly increased the heart's refractory period, which helps prevent irregular heartbeats, and reduced both the duration and frequency of AF episodes. This suggests that Ivabradine could be a helpful treatment option for older dogs suffering from this type of heart problem.
People also search for: dog atrial fibrillation treatment · Ivabradine for dogs heart problems · aging dog heart disease management
Abstract
BACKGROUND: Ivabradine is an inhibitor of mixed Na+-K+ current that could combine with HCN channels to reduce the transmembrane velocity of funny current (If), heart rate, and cardiac efficiency, and thus be used for the treatment of cardiovascular diseases such as chronic heart failure. As an ion channel blocker, Ivabradine is also a potential antiarrhythmic agent. MATERIAL/METHODS: Twelve aging dogs (8-10 years old) underwent rapid atrial pacing for 2 months to induce age-related AF in this study. The dogs were randomly divided into the Ivabradine group and aging-AF group. The effects of Ivabradine on the electrophysiological parameters, including the effective refractory period (ERP) of the pulmonary veins and atrium, duration of AF, and inducing rate of AF, were investigated. RESULTS: As compared to the aging-AF group, the ERPs of the left superior pulmonary vein (139.00±4.18 ms vs. 129.00±4.08 ms, P=0.005) and left auricle (135.00±3.53 ms vs. 122.00±4.47 ms, P=0.001) were significantly increased, while the duration of AF (46.60±5.07 s vs. 205.40±1.14 s, P=0.001) and inducing rate of AF (25% vs. 60%, P=0.001) were significantly decreased. CONCLUSIONS: Ivabradine could effectively reduce the inducing rate of AF, and thus be used as an upstream drug for the prevention of age-related AF.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/25982136/