Peer-reviewed veterinary case report
Effects of Justicia acuminatissima, or Amazonian Sara Tudo, on ischemic acute kidney injury: an experimental study.
- Journal:
- Revista da Escola de Enfermagem da U S P
- Year:
- 2019
- Authors:
- Cordeiro, Priscilla Mendes et al.
- Affiliation:
- Universidade Federal do Amazonas · Brazil
- Species:
- rodent
Abstract
OBJECTIVE: To evaluate the effects of Justicia acuminatissima , or Amazonian Sara Tudo , on renal hemodynamics, oxidative profile, and renal histology in rats with ischemic acute kidney injury. METHOD: Preclinical assay with adult male Wistar rats, weighing from 250 g to 350 g, distributed into Sham, ischemia, and ischemia + Sara Tudo groups. Hemodynamic parameters, renal function, oxidative stress, and renal histology were evaluated. RESULTS: Pretreatment with Sara Tudo reduced the functional injury, which was shown by the increase in creatinine clearance and thiols; reduction of oxidative markers, renal vascular resistance, and tubulointerstitial injury in the renal tissue; and the significant improvement in renal blood flow. CONCLUSION: The renoprotection provided by Justicia acuminatissima , or Sara Tudo , in cases of ischemic acute kidney injury was characterized by a marked improvement in renal function, reducing the oxidative injury, and impacting on renal histology positively.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31433017/