Peer-reviewed veterinary case report
Effects of mannooligosaccharides from coffee mannan on blood pressure in Dahl salt-sensitive rats.
- Journal:
- Journal of nutritional science and vitaminology
- Year:
- 2008
- Authors:
- Hoshino-Takao, Izumi et al.
- Affiliation:
- R & D and Engineering Deptartment · Japan
- Species:
- rodent
Abstract
Dahl salt-sensitive (Dahl-S) rats, serving as a model of hereditary hypertension, were used to examine the effect of mannooligosaccharides (MOS) on blood pressure. Dahl-S rats were induced to develop hypertension by administering them with a 1.25% salt solution ad libitum. In a 10-wk experimental period, the Dahl-S control and MOS groups developed and maintained significantly higher blood pressure than the Dahl salt-resistant normal control group. The MOS group showed a significantly lower blood pressure than the Dahl-S control group after 5-wk of treatment (p<0.05). In addition, the serum aldosterone level of the MOS group significantly decreased (p<0.05). The findings of this study using a model of hypertensive rats suggest that MOS are able to suppress an elevation in blood pressure.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/18490850/