Peer-reviewed veterinary case report
Itraconazole raises cyclosporine levels in cats after multiple doses
By Katayama, Masaaki et al.·Published in Journal of feline medicine and surgery·2010·Department of Veterinary Medicine, Japan·View original on PubMed →
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Original publication title: Effects of multiple oral dosing of itraconazole on the pharmacokinetics of cyclosporine in cats.
- Species:
- cat
Plain-English summary
Three healthy cats were given a common antifungal medication, itraconazole, along with a drug called cyclosporine, which is often used to help prevent organ rejection in kidney transplants. The study found that when itraconazole was given with cyclosporine, it significantly increased how much of the cyclosporine was available in the cats' bodies. This suggests that using itraconazole could allow for lower doses of cyclosporine to be effective in treating cats that have undergone kidney transplants.
People also search for: cat kidney transplant medication · itraconazole effects on cyclosporine in cats · cyclosporine dosage for cats
Abstract
Itraconazole (Icz) has been known to increase the cyclosporine (CsA) trough level in human transplant patients. However, the interaction of Icz with CsA has not been reported in cats. In this study, the effect of multiple dosing of Icz on the pharmacokinetics of CsA in three healthy cats was investigated. The treatments included CsA 5mg/kg alone and CsA 5mg/kg+multiple-dose of Icz 10mg/kg. Co-administration of Icz with CsA resulted in significant increases of oral bioavailability of CsA. The results of our study suggest that administration of multiple therapeutic doses of Icz may decrease the required CsA dosage in CsA-based immunosuppressive therapy used for renal transplantation in cats.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/20371199/