Peer-reviewed veterinary case report
Effects of NADinModels of Neuronal Damage.
- Journal:
- Biomolecules
- Year:
- 2020
- Authors:
- Lee, Yuri et al.
- Affiliation:
- Department of Life Science · South Korea
Abstract
Nicotinamide adenine dinucleotide (NAD) is an essential cofactor that mediates numerous biological processes in all living cells. Multiple NADbiosynthetic enzymes and NAD-consuming enzymes are involved in neuroprotection and axon regeneration. The nematodehas served as a model to study the neuronal role of NADbecause many molecular components regulating NADare highly conserved. This review focuses on recent findings usingmodels of neuronal damage pertaining to the neuronal functions of NADand its precursors, including a neuroprotective role against excitotoxicity and axon degeneration as well as an inhibitory role in axon regeneration. The regulation of NADlevels could be a promising therapeutic strategy to counter many neurodegenerative diseases, as well as neurotoxin-induced and traumatic neuronal damage.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/32630651/