Peer-reviewed veterinary case report
Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain.
- Journal:
- Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine
- Year:
- 2012
- Authors:
- Kaulaskar, Shyam et al.
- Affiliation:
- Post-Graduate Research Department · India
- Species:
- rodent
Abstract
OBJECTIVE: To study the analgesic effects of naringenin on chronic constriction injury (CCI) model of neuropathic pain. METHODS: After inducing of neuropathic pain by CCI, treatment with 25 and 50 mg/kg of naringenin and 10 mg/kg of pregabalin was given. Rats were evaluated for behavioral tests using Hargreaves apparatus for thermal hyperalgesia, pin prick test for tactile mechanical hyperalgesia and cold water-induced allodynia on days 0, 3, 5, 7, 14 and 21. At the end of study, oxidative stress parameters were measured. RESULTS: Naringenin showed ameliorating action against CCI-induced neuropathic pain in all the tested models. Also, naringenin attenuated the elevated levels of lipid peroxidation and nitric oxide, and restored the level of reduced glutathione. CONCLUSION: The results of the present investigation suggest that naringenin exhibits analgesic effect in sciatic nerve injury model.
Find similar cases for your pet
PetCaseFinder finds other peer-reviewed reports of pets with the same symptoms, plus a plain-English summary of what was tried across them.
Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/23257145/