Peer-reviewed veterinary case report
How nitric oxide synthase inhibitor affects dog digestion functions
By Tanaka, Toshiyuki et al.·Published in Experimental animals·2005·Second Department of Surgery, Japan·View original on PubMed →
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Original publication title: Effects of nitric oxide synthase inhibitor on the digestive system measured by simultaneous monitoring of gastric motility, gastric emptying activity and postprandial pancreaticobiliary secretion in dogs.
- Species:
- dog
Plain-English summary
A group of six mongrel dogs had a special treatment to see how a nitric oxide synthase inhibitor (L-NNA) affected their digestion. After giving the dogs this medication, researchers found that while their stomach muscles worked harder after eating, the food was not moving out of the stomach as quickly as it should. Additionally, the dogs produced less digestive enzymes and bile during the first hour after eating. This suggests that the medication may slow down how quickly food and digestive juices are released into the intestines, which could affect their overall digestion.
People also search for: dog digestive issues · why is my dog not digesting food · treatment for dog stomach problems
Abstract
Relationships between the NO synthase inhibitor and gastric and pancreaticobiliary functions measured simultaneously in the digestive state have been little studied. The aim of this study was to estimate the effect of NO synthase inhibitor on integrated digestive function in conscious dogs. A strain gauge force transducer was implanted on the gastric antrum of 6 mongrel dogs to measure gastric contractile activity and two duodenal cannulas were inserted into the proximal and distal sites to measure the gastric emptying rate and the pancreaticobiliary output into the duodenum using our novel method. Postprandial pancreatic and biliary secretion were presented as amylase and bile acid activity, respectively. Furthermore, a cervical cannula was placed into the superior vena cava as a route for the administration of NO synthase inhibitor, N omega-nitro-L-arginine (L-NNA), at a dose of 2.5 mg/kg-h. In a group given L-NNA, gastric contractile activity after ingestion was significantly enhanced, but the emptying rates of gastric solids and liquids were significantly suppressed in comparison with the control. The mean 0-1 h amylase integrated output was significantly (P < 0.05) decreased in comparison with the control, and the mean bile acid integration of 0-1 h output was also significantly (P < 0.01) decreased. A possible explanation for this observation is that smaller volumes of nutrient are delivered into the duodenum; however, it could also be that postprandial pancreaticobiliary secretion is inhibited by an alteration of blood flow or by a change in contractions of the sphincter of Oddi after the administration of L-NNA.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16093644/