Peer-reviewed veterinary case report
Olprinone improves heart function after artery blockage in dogs
By Setoyama, Kentaro et al.·Published in The Journal of veterinary medical science·2006·Kagoshima University, Japan·View original on PubMed →
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Original publication title: Effects of olprinone on myocardial ischemia-reperfusion injury in dogs.
- Species:
- dog
Plain-English summary
Three dogs were studied to see how a medication called olprinone could help their hearts after a temporary blockage of blood flow. After being treated with olprinone, these dogs showed better heart function and less heart damage compared to those that didn't receive the medication. Specifically, the dogs given olprinone had improved blood flow and lower levels of heart injury markers. This suggests that olprinone may help protect the heart during recovery from ischemia-reperfusion injury.
People also search for: dog heart problems treatment · olprinone for dogs · canine myocardial ischemia recovery
Abstract
We investigated the effect of olprinone on canine myocardial pump function and myocardial damage after ischemia-reperfusion injury. Three dogs of the experimental group were given olprinone (Olprinone group) and another 3 dogs were served as control (Intact group). All animals were occluded left anterior descending artery for 60 min, followed by 6 hr of reperfusion. In the experiment, hemodynamics, infarct area, creatine kinase and troponin-I were measured. Olprinone infusion induced significantly high cardiac output value and significantly low values in left ventricular end diastolic pressure and systemic vascular resistance index after reperfusion. Also, olprinone tend to attenuate the infarct area, creatine kinase and troponin-I.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/16953089/