Peer-reviewed veterinary case report
How prednisone affects cystatin C blood levels in dogs
By Muñoz, J et al.·Published in Journal of veterinary internal medicine·2017·Animal Medicine Department, Spain·View original on PubMed →
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Original publication title: Effects of Oral Prednisone Administration on Serum Cystatin C in Dogs.
- Species:
- dog
Plain-English summary
A group of dogs with steroid-responsive meningitis arteritis (SRMA) were given oral prednisone to see how it affected their kidney function. After one week of treatment, the dogs showed higher levels of a kidney function marker called serum cystatin C, but these levels returned to normal after reducing the prednisone dose and stopping it altogether. This suggests that while prednisone can temporarily raise this marker, it does not indicate lasting kidney damage in healthy dogs. If your dog is on prednisone, it's important to monitor their kidney health, but the effects may be reversible.
People also search for: dog prednisone side effects · SRMA treatment in dogs · kidney function tests for dogs on steroids
Abstract
BACKGROUND: Oral administration of glucocorticoid alters serum cystatin C (sCysC) concentration in humans. OBJECTIVE: To determine if oral administration of prednisone alters sCysC in dogs without pre-existing renal disease. ANIMALS: Forty six dogs were included: 10 dogs diagnosed with steroid responsive meningitis arteritis (SRMA; group A), 20 dogs diagnosed of pituitary-dependent hyperadrenocorticism (PDH; group B), and 16 healthy control dogs (group C). METHODS: Retrospective observational study. SRMA diagnosed dogs were administered prednisone 4 mg/kg/24 h PO 7 days, reducing the dose to 2 mg/kg/24 h 7 days before medication withdrawal. In group A, sampling was performed at days 0, 7, 14 and a final control at day 21. Blood and urine samples were collected in the 3 groups, and in group A, sampling was performed at all time points (days 1, 7, 14, and 21). RESULTS: In group A, sCysC was significantly higher at day 7 compared to the control group (0.4 ± 0.04 mg/L vs. 0.18 ± 0.03 mg/L mean ± SEM respectively P < 0.01); sCysC values decreased to basal at day 14 when the dose was decreased and after 1 week of withdrawal of prednisone (0.27 ± 0.03 mg/L for group A at day 14 and 0.15 ± 0.02 mg/L at day 21; P > 0.05). Dogs with PDH included in group B did not have significant differences in sCysC (0.22 ± 0.03 mg/L) compared to control (P > 0.05). CONCLUSIONS AND CLINICAL IMPORTANCE: Oral administration of prednisone unlike altered endogenous glucocorticoid production, increases sCysC in dogs in a dose-dependent fashion.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/28921665/