Peer-reviewed veterinary case report
Oral and injection B12 supplements lower harmful acids in dogs
By Toresson, L et al.·Published in Veterinary journal (London, England : 1997)·2019·Department of Equine and Small Animal Medicine·View original on PubMed →
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Original publication title: Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations.
- Species:
- dog
Plain-English summary
A group of 36 dogs with low vitamin B12 levels (cobalamin) were treated with either oral or injectable cobalamin supplements to see which worked better. After 28 days, both groups showed significant improvements in their methylmalonic acid levels, a marker of cobalamin deficiency, but there was no notable difference between the two methods. By the end of the study, both oral and injectable supplements were effective in raising cobalamin levels in these dogs. This means that pet owners can choose either method based on their preference or their dog's needs.
People also search for: dog low vitamin B12 treatment · oral vs injectable cobalamin for dogs · dog methylmalonic acid levels
Abstract
The objective of this study was to compare the effects of parenteral (PE) versus oral (PO) cobalamin supplementation on serum methylmalonic acid (MMA) and homocysteine (HCY) concentrations in dogs with hypocobalaminaemia. Thirty-six dogs with serum cobalamin concentrations below 285ng/L (reference interval (RI): 244-959ng/L) were treated with PO (0.25-1.0mg daily) or PE cobalamin (0.25-1.2mg/injection) using a block-randomized schedule. Serum MMA and HCY concentrations were analysed at day 0, 28 and 90 after start of supplementation. There was no significant difference between the PO and PE group regarding serum MMA or HCY concentrations at any time point. Median (range, P comparing baseline and 28 days, P comparing 28days and 90 days) serum MMA concentrations (nmol/L; RI 415-1193) were 932 (566-2468) in the PO and 943 (508-1900) in the PE group at baseline, respectively, 705 (386-1465, P<0.0001) and 696 (377-932, P<0.0001) after 28 days, and 739 (450-1221, P=0.58) and 690 (349-1145, P=0.76) after 90 days. Serum HCY concentrations (median (range), P comparing baseline and 28 days, P comparing 28days and 90 days, μmol/L; RI 5.9-31.9) in the PO and PE groups were 12.2 (3.3-62.2) and 8.4 (3.7-34.8) at baseline, 12.5 (5.0-45.0, P=0.61) and 8.0 (3.8-18.3, P=0.28) after 28 days, and 17.7 (7.3-60.0 P=0.07) and 12.4 (6.3-33.1, P=0.0007) after 90 days, respectively. Oral and parenteral cobalamin supplementation had the same effect on serum MMA concentrations in this group of dogs.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/30606444/