Peer-reviewed veterinary case report
Palmitoylethanolamide reduces skin allergy swelling
By Cerrato, Santiago et al.·Published in Veterinary journal (London, England : 1997)·2012·UNIVET, Spain·View original on PubMed →
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Original publication title: Effects of palmitoylethanolamide on the cutaneous allergic inflammatory response in Ascaris hypersensitive Beagle dogs.
- Species:
- dog
Plain-English summary
A group of six Beagle dogs with allergies to Ascaris (a type of roundworm) were given palmitoylethanolamide (PEA), a natural substance that helps reduce inflammation, to see if it would help with their skin reactions. After taking PEA, the dogs showed a significant decrease in swelling and redness caused by allergic reactions. The best results came from a dose of 10 mg/kg, which worked well and lasted longer than the amount of PEA in their blood. This suggests that PEA could be a promising new treatment for dogs with allergic skin issues.
People also search for: Beagle dog skin allergies treatment · palmitoylethanolamide for dogs · dog allergic reaction to Ascaris · anti-inflammatory for dog skin problems
Abstract
Palmitoylethanolamide (PEA) is an endogenous lipid mediator with anti-inflammatory and anti-hyperalgesic properties. The main objective of the present study was to evaluate the effects of PEA on the cutaneous allergic inflammatory reaction induced by different immunological and non-immunological stimuli in hypersensitive dogs. Six spontaneously Ascaris hypersensitive Beagle dogs were challenged with intradermal injections of Ascaris suum extract, substance P and anti-canine IgE, before and after a single oral administration of PEA at doses of 3, 10 and 30 mg/kg. A significant reduction in wheal area induced by both antigen and anti-canine IgE challenge was observed after PEA administration. No significant differences were observed between the two higher doses studied, suggesting that the 10 mg/kg dose had exerted the maximum inhibitory effect. When blood levels of PEA were compared with the effects at different times, an evident correlation was obtained. However, the anti-inflammatory effects of PEA were more long-lasting than their plasma concentrations. The intradermal injection of substance P did not reveal any skin reaction (wheal or erythema formation) at any of the concentrations tested. In conclusion, PEA might constitute a new therapeutic strategy for the treatment of allergic inflammatory skin diseases in companion animals.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/21601500/