Peer-reviewed veterinary case report
Effects of pixantrone on immune-cell function in the course of acute rat experimental allergic encephalomyelitis.
- Journal:
- Journal of neuroimmunology
- Year:
- 2005
- Authors:
- Mazzanti, Benedetta et al.
- Affiliation:
- Department of Neurological and Psychiatric Sciences · Italy
- Species:
- rodent
Abstract
Pixantrone is an immunesuppressor similar to mitoxantrone but with lower cardiotoxicity. We evaluated the effect of pixantrone on B cells and lymphomononuclear cells in the course of acute EAE. Pixantrone reduced the number of B cells and suppressed myelin basic protein (MBP) specific IgG production. In vitro, pixantrone induced apoptosis of rat B lymphocytes in a way similar to mitoxantrone. In addition, pixantrone inhibited antigen specific and mitogen induced lymphomononuclear cell proliferation, as well as IFN-gamma production, during EAE. These findings suggest a similar mechanism of action for pixantrone and mitoxantrone on the effector function of lymphomonocyte B and T cells.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16120465/