Peer-reviewed veterinary case report
How propofol and ketamine affect eye pressure in dogs
By Şenocak, Mümin Gökhan & Yanmaz, Latif Emrah·Published in Veterinary ophthalmology·2024·Department of Surgery·View original on PubMed →
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Original publication title: Effects of propofol alone or in combination with ketamine on intraocular pressure in unpremedicated dogs.
- Species:
- dog
Plain-English summary
A group of 28 healthy dogs were given either propofol alone or a combination of propofol and ketamine to see how it affected their eye pressure. The results showed that all treatments increased eye pressure, but the combination of propofol and ketamine at a 1:2 ratio had a less significant effect on eye pressure for the first 45 minutes. It was also found that low oxygen levels in the dogs could lead to higher eye pressure. This information is important for veterinarians when considering anesthesia options for dogs, especially those with existing eye pressure concerns.
People also search for: dog eye pressure treatment · propofol effects on dogs · ketamine anesthesia for dogs
Abstract
OBJECTIVE: To determine the effects of propofol (P) alone and in combination with ketamine (KP) at ratios of 1:1, 1:2, and 1:3 on intraocular pressure (IOP) in unpremedicated dogs. ANIMALS STUDIED: A total of 28 cross-bred healthy dogs. PROCEDURES: Dogs were randomly assigned to one of four groups (n = 7 per group) to receive intravenous P or KP at 1:1, 1:2, and 1:3 ratios, respectively. The infusion was administered at 0.6 mg/kg/min for 60 min. IOP, cardiorespiratory variables, rectal temperature (RT), and pedal reflex were recorded every 5 min for 60 min, starting from baseline (BL). RESULTS: There was a statistically significant increase in IOP in all groups: P (p = .011), KP 1:1 (p = .003), KP 1:2 (p = .023), and KP 1:3 (p = .008). The IOP increase was less pronounced in the KP 1:2 group and was only significant (p = .023) at T45 compared with BL. A significant correlation was observed between IOP and SpOin P (r = -.215, p = .02), KP 1:2 (r = -.579, p < .01), and KP 1:3 (r = -.402, p < .01) groups. IOP significantly increased due to decreased SpObelow 86.5% (p < .05). CONCLUSIONS: Propofol alone and in combination with ketamine may increase preexisting IOP in unpremedicated dogs. SpOlevels below 86.5% may trigger an increase in IOP. Administering KP in a 1:2 ratio at an infusion rate of 0.6 mg/kg/min does not significantly alter IOP for under 45 min in unpremedicated dogs with sufficient oxygenation.
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Search related cases →Original publication on PubMed: https://pubmed.ncbi.nlm.nih.gov/37395174/