Peer-reviewed veterinary case report
Effects of PRRSV Infection on the Porcine Thymus.
- Journal:
- Trends in microbiology
- Year:
- 2020
- Authors:
- Wang, Gang et al.
- Affiliation:
- Harbin Veterinary Research Institute · United States
Abstract
Porcine reproductive and respiratory syndrome virus (PRRSV) dramatically affects the thymus and its ability to carry out its normal functions. In particular, infection incapacitates PRRSV-susceptible CD14antigen-presenting cells (APCs) in the thymus and throughout the body. PRRSV-induced autophagy in thymic epithelial cells modulates the development of T cells, and PRRSV-induced apoptosis in CD4CD8thymocytes modulates cellular immunity against PRRSV and other pathogens. Pigs are less able to resist and/or eliminate secondary infectious agents due the effect of PRRSV on the thymus, and this susceptibility phenomenon is long recognized as a primary characteristic of PRRSV infection.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/31744664/