Peer-reviewed veterinary case report
Effects of reserpine on the plus-maze discriminative avoidance task: dissociation between memory and motor impairments.
- Journal:
- Brain research
- Year:
- 2006
- Authors:
- Carvalho, Rita C et al.
- Affiliation:
- Department of Pharmacology · Brazil
- Species:
- rodent
Abstract
We investigated the effects of reserpine (0.1-0.5 mg/kg) on the performance of mice in the plus-maze discriminative avoidance task (DAVT), which simultaneously evaluates memory and motor activity. All doses induced memory impairment (increased aversive arm time) but only 0.5 mg/kg reserpine decreased locomotion (entries in enclosed arms). The results suggest that the DAVT evaluation in reserpine-treated mice can be a useful model for studying cognitive deficits accompanied by motor impairments.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/17030027/