Peer-reviewed veterinary case report
Effects of sabiporide, a specific Na+/H+ exchanger inhibitor, on neuronal cell death and brain ischemia.
- Journal:
- Brain research
- Year:
- 2005
- Authors:
- Park, Hye-Seong et al.
- Affiliation:
- Department of Physiology · South Korea
Abstract
We investigated the effects of an Na(+)/H(+) exchanger inhibitor, sabiporide, on excitotoxicity in cultured neuronal cells and in vivo. Sabiporide attenuated glutamate- or NMDA (N-methyl-d-aspartic acid)-induced neuronal cell death. Sabiporide also reduced glutamate or NMDA-induced increase in [Ca(2+)](i). In in vivo brain ischemia model, sabiporide produced protective effects, decreasing the infarct size and edema volume. Our results suggest that sabiporide elicits neuroprotective effect both in vitro and in vivo.
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Search related cases →Original publication: https://pubmed.ncbi.nlm.nih.gov/16225853/